The actor-slash-rocker will host this year's version of the anything-can-happen extravaganza, set for Aug. 31, MTV announced Thursday.
"Prepare yourself for a rip snortin' humdinger," Black said. "I am Jables, hear me roar."
The awards will air live from Radio City Music Hall in New York. Performers include Beyonce, Justin Timberlake, Panic! at the Disco, and Ludacris.
Black, 34, is the "perfect mix of comedy, rock, irreverence and star power," MTV President Christina Norman said in a statement.
Black's films include "Nacho Libre," "King Kong" and "School of Rock." He'll next be seen with his Tenacious D bandmate, Kyle Gass, in the semi-autographical comedy "Tenacious D in 'The Pick of Destiny,' " slated for release Nov. 17.